Even if Isaac have not finished charging Brimstone when he'll pass through a door, it is always fully charged once a new room is entered if the fire button is still being held. Rooms This will heal red hearts and then give soul hearts up to a total of 6. The room doors will open if only frozen enemies remain, UNLOCK: Unlock this trinket by defeating challenge #41 (Pica Run), Every time you kill an enemy you get an invincibility shield for 1 second, While shielded, each enemy killed adds +1 seconds to the duration, UNLOCK: Unlock this trinket by defeating challenge #37 (Bloody Mary), * item room, treasure room, item room pool, green, cry, plant, Tears now shoot three at a time (Triple Shot). Brimstone Bombs: Brimstone beams will shoot out upon exploding. Hook Worm, Wiggle Worm etc. It's the run that keeps on giving and continues to get stronger the farther you get. Effects * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Transformations It stops moving while Isaac is firing tears and upon releasing the fire button, King Baby will teleport back to your location, King Baby will always appear first in the queue of familiars, REPENTANCE - Familiars now automatically aim at enemies when being commanded by King Baby. +1 flat damage. If combined with My Reflection, the beam will first wrap around Isaac, form an oval beam in a longer range, then shoot backward. Using the Red Key near it will spawn a red room, This room will randomly choose from many types, including (but not limited to) any regular room from that floor, treasure rooms, curse rooms, devil rooms, angel rooms, I AM ERROR rooms and more, In rooms with multiple door outlines, the closest one will be opened, Attempting to create a room outside the maximum boundary (13 x 13 rooms) of the map will take you to an I AM ERROR room. REPENTANCE - The Nail's temporary damage bonus has been increased, and is now able to stack with itself. The bigger beam granted by double Brimstone synergizes with other items as expected. Curses Boosts speed, range, shot speed, tears and damage if they are above their base values by roughly +20%, Affects stat bonuses from passive items, trinkets that are absorbed or in a second trinket slot, and permanent bonuses given by items such as Void, UNLOCK: Unlock this trinket by getting a 5-win streak in daily challenges (must have a score of above 0 on the score screen), While held, gives the Skatole effect only in certain rooms, which will turn hostile flies to neutral and stop others from shooting, Attack, Dart and Ring Flies turn into neutral Black Flies and Pooters and Fat Flies will no longer fire at you, Items and trinkets which generate blue flies and spiders will have double the effect, causing twice as many to spawn, *, grey, gray, green, arrow, flower, plant, Some tears will randomly become a black tooth, that deal double your normal tear damage and can poison enemies, Tears become spectral and travel in a huge spiral pattern, Every time you take damage you have a very small chance to gain a Tonsil familiar, which follows you and blocks enemy projectiles, This effect can happen twice before the Tonsil trinket is destroyed, Your tears have a random chance to become booger tears, Booger tears stick on to enemies and deal periodic poison damage until they die or 60 seconds passes. When used, it retrieves the Forgotten skull, causing it to shoot back into your arms, Tainted Bethany - Spawns four random item wisps of high quality with significantly higher HP than normal, Tainted Jacob - Dark Esau splits into 2. +0.5 tear falling speed. The Knife Piece 1 is located in the Item Room in the mirrored area. Cosmetic change only. purple, pink, mask, face, Puts a shield in front of Isaac which blocks projectiles, The shield will rotate based on the direction in which Isaac is firing tears, * angel room pool, god room pool, angel room item, blue, silver, metal, Gives Isaac a laser that will fire at random intervals in addition to your normal tears, Each laser does damage equal to your current tear damage, The laser will occasionally fire with one of these effects: Hook Worm, Spoon Bender, Tiny Planet, Mysterious Liquid, Rubber Cement, Luck has no effect on the rate at which Tech.5 fires and does not scale with items that increase your tears stat, UNLOCK: Unlock this item by beating Challenge #18 (The Host), * technology.5, tech 5, item room, treasure room, item room pool, white, red, eye, robot, Isaac now shoots two tears at once, but dealing -20% damage each, Unlike the Inner Eye and Mutant Spider items, this double shot item does not give a tears down, * 20 20, 2020, item room, treasure room, item room pool, black glasses, spectacles, Reveals the locations of the secret and super secret room for the current floor and all future floors, UNLOCK: Unlock this item by donating 10 pennies to the Shop, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, This is shown by the Azazel skin spreading on Isaac's face, After 4 rooms, Isaac's face will flash red. One of the following messages may show: "Some doors require a blessing. 's unique poops, Corn poop - Spawns a blue fly every 2 seconds, Flaming poop - Leaves behind fire that damages enemies, Black poop - Creates slowing black creep. Bloody Lust Damage Up for the rest of the floor when the player takes damage. Release Brimstone and tap multiple times in the direction Isaac fired. UNLOCK: Unlock this card by beating Challenge #12 (When Life Gives You Lemons), When used, will open all doors in the current room, similar to a one-time use of Dad's Key, UNLOCK: Unlock this card by beating Challenge #22 (Speed), When used this card will activate a use of your spacebar item for free, When used, this rune will destroy all breakable objects in the current room, such as poop, rocks, secret room entrances, UNLOCK: Unlock this card by beating Challenge #1 (Pitch Black), When used this rune will double all pickups on the floor in the room, Creates copies of pickups in the Shop which can be taken for free, even if you haven't purchased them yet, Can be used to double the number of item chests in the first room of the final Chest / Dark Room floors, Cloned chests have the same types of items as the first one, Cannot be used to clone trinkets or other Jera runes, UNLOCK: Unlock this card by beating Challenge #2 (High Brow), UNLOCK: Unlock this card by beating Challenge #3 (Head Trauma), Removes the curse which is in effect on the current floor (except Curse of the Labyrinth), Can also cure the effect of the Amnesia pill, UNLOCK: Unlock this card by beating Challenge #4 (Darkness Falls), When used, reveals the entire map including all the secret room locations and other icon rooms, UNLOCK: Unlock this card by beating Challenge #5 (The Tank), Rerolls all pedestal items in the current room (One time use of the D6), UNLOCK: Unlock this card by beating Challenge #6 (Solar System), Summons 3 blue friendly spiders and 3 blue flies, UNLOCK: Unlock this card by beating Challenge #20 (Purist), When used, gives you an invincibility effect which lasts for 20 seconds, UNLOCK: Unlock this card by beating Challenge #8 (Cat Got Your Tongue), When used, gives a random Mystic rune effect, Possible effects include: Algiz, Ansuz, Berkano, Dagaz, Ehwaz, Hagalaz, Jera, Perthro, Also has a 25% chance to spawn another Blank Rune upon use, UNLOCK: Unlock this card by beating Challenge #30 (Guardian), When used, this rune deals 40 damage to all enemies in the room and consumes all pedestal items in the room, giving you a random stat increase for each item consumed, Also consumes all pickups in the room and turns them into blue flies and spiders, UNLOCK: Unlock this item by beating Greedier mode as Apollyon. from Fireplaces, Gives you a familiar which is a smaller version of the Plum boss, which sprays tears and propels itself around the room, Deals 2 contact damage per tick to enemies, and the tears deal 3 damage each, Deals contact damage to any enemies it runs into, UNLOCK: Unlock this item by beating Baby Plum 10 times, When used, this item calls a friendly version of the Plum boss to fight for you for 10 seconds, It will jump to the nearest enemy, slam on the ground and fire tears around it, then propel itself around the room, dealing contact damage to any enemies it touches before disappearing, It's possible to get a guaranteed spawn of this item by encountering the Baby Plum boss and not damaging her. The longer the button is held the faster Gurdy will fling itself across the screen, Deals a fixed amount of damage depending on charge level, at lowest being ~5 and at max being ~20, Lil Gurdy bounces off of enemies and obstacles, A beggar head which floats around the room and picks up any nearby coins. shop item pool, brown, x, cross, paper, Isaac has a random chance to fire another tear out the back of his head, The chance to fire the second tear can improve based on your luck stat and will always activate at +5 Luck, At +0 luck theres a ~50% chance for this effect to activate, Synergizes very well with a lot of items. Dead Bird) then Box of Friends will cause it to spawn but won't create duplicates, This can be used multiple times in the same room to generate more familiars, meaning you can get a level 4 meatboy or bandage girl by using this item 3 times in the same room, If used when you have no familiars, it will give you a Demon Baby temporarily, UNLOCK: Unlock this item by beating Greed Mode with Lilith, Isaac wears a dunce hat and fires 2 tears at once diagonally, similar to the R U A WIZARD pill tear pattern, * Item Room, Greed Mode Item Room, dunce cap, white, hat, cone, Replaces Isaac's tears with nails, which have increased knockback, The increased knockback will also affect Brimstone, which usually has no knockback at all, Gives you a familiar demon incubus that follows you and shoots tears that scale with your own tears in terms of damage, stats and also effects, It will mimic any tear effects you currently have and also copy your current stats, meaning it will fire with the same damage, fire rate and range, Incubus' damage is reduced by 25% when playing as characters other than Lilith, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Lilith, Item Pool: Devil Room, Greed Mode Devil Room, A familiar blue head that will follow Isaac and fire tears copying his tear damage and effects, This familiar is very similar to Incubus, however it only copies damage and is not affected by tears or range upgrades, UNLOCK: Unlock this item by beating Blue Womb (Hush) with ??? 3 keys = 25% chance. Attributes Counts as 1 of 3 spider items needed towards the Spider Baby transformation. Blue Baby, The Lost), * devil pool, devil room pool, devil deal, red, black, star, moon, When used, gives a random familiar for the entire floor. Pickups Notes: Very fun Isaac seed that leads to some interesting synergies, particularly if playing as Azazel. Rooms The spear occasionally inflicts fear on enemies it damages. A familiar baby that fires tears which have a chance to freeze or petrify enemies, Counts as 1 of 3 familiar items needed towards the Conjoined transformation, When used, rerolls all items in the room into another random item from the current room's item pool, however the item also has a 30% chance to disappear, The chance associated with this item does NOT scale with your Luck stat - it's always 30%, In the game files this item is called 'Florians Dice', which is a reference to the Eternal update for the original Binding of Isaac game, which changed the D6 to act as this item does. poop, When used, you have a 50% chance to double all items, consumables and chests in the current room, If the effect fails, all pickups and items are deleted and Crooked Penny spawns 1 coin, If there are no consumables currently on the floor, Crooked Penny spawns 1 coin, This item works with items which can be purchased such as shop items, allowing you to spawn a free version if the effect triggers, If used in a shop and the effect fails, a Restock box can be used to restore the shop items. If used in a room with no enemies, Dark Esau will instantly spawn, Will chain up to two targets if you have Car Battery, if only one valid target is present it will be chained for twice the duration, UNLOCK: Unlock this item by defeating Delirium as Tainted Jacob, Rerolls all pedestal items, lowering all their internal item IDs by 1, For example: Brimstone's ID = 118, so it would be rerolled into Dead Bird (ID = 117), Sad Onion (ID = 1) will reroll into nothing, There are some gaps in item IDs which are skipped if no item exists, or will reroll into unexpected items if hidden items are present at that ID. A familiar that follows Isaac and charges forwards very slowly, dealing 2.7 damage per tick to any enemies it comes into contact with, Almost identical to the Little Chubby familiar, but this one moves much more slowly and deals less damage, REPENTANCE - The damage tick rate on Big Chubby has been increased, Upon use, this item deals 9,999,999 damage to all enemies in the room and then kills you 3 seconds later, This is a single use active item, meaning it is destroyed after using it, Does not kill both phases of multi-phase bosses like Hush or Ultra Greed, If used to kill a boss, the kill still counts as a victory for post-it note completion marks, but the run will still get a game over, Delirium's death animation takes longer than 3 seconds, meaning you will die before it can count as a completion mark. After which, the only way to access an Angel Room is via the Sacrifice Room, * curse room pool, red chest pool, red chest item pool, golden chest pool, gold chest pool, devil pool, devil room pool, devil deal, brown, horns, When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool, The size resets when leaving the floor, UNLOCK: Unlock this item by defeating The Beast as Tainted Lazarus, A fetus familiar follows Isaac, and upon entering the Boss room on each floor, it will transform into a copy of the boss, This makes bosses a lot harder, however you now get 2 boss item drops, UNLOCK: Unlock this item by defeating Hush as Jacob & Esau, You gain two familiar demons, that stay by Isaac's side and fire shots in the same direction as you, The familiars deal roughly 40% of Isaac's damage, scaling with damage upgrades you get, They sit near and rotate around Isaac depending on which way you're firing tears. Passive rooms with no enemies don't have a chance to spawn Red Rooms. This deals 1 damage per tick, High tear damage will cause this item to become very powerful for rooms with a lot of enemies, since they can die instantly and render the room harmless, Enemies which spawn after the first few seconds of each room are not affected by this item, e.g. Tears are fired in an arc. 'One Makes you Larger' pills, Magic Mushroom etc, *, mtg, card, magic, gathering, green, brown, giant growth, Spawns 3 random cards on the floor when used, When used, this card will slow down enemies, Isaac's tears by -1 Shot Speed, but speed up Isaac's movement speed by +0.50 for the rest of the current room, UNLOCK: Unlock this item by getting both the Broken Watch and the Stop Watch in your collection, When used, removes the price tag from all items in the current shop or devil deal, making everything free, The effect of the Credit Card only lasts for the current room, UNLOCK: Unlock this card by beating Challenge #10 (Cursed!). Tears down: Delay * 3. After a few seconds a huge missile hits the target and deals 20x your tear damage to anything nearby, Essentially a one-time use of the Epic Fetus item, * item room, treasure room, item room pool, grey, gray, robot, Isaac's tears now have a piercing effect which allows them to travel through enemies instead of breaking on hit, * item room, treasure room, item room pool, arrow, penetrative, penetrating shots, grey, gray, One exception to this is if you are playing as Lazarus or have Lazarus' Rags - you will respawn in the same room and get the kill, Plan C is 5 times rarer than other items in the same item pool, making it less likely to appear, UNLOCK: Unlock this item by defeating Greedier Mode with Lazarus, Item Pool: Shop, Devil Room, Curse Room, Red Chest, Demon Beggar, When used, the D1 duplicates 1 random pickup in the current room. PC 9SS3 3YXY (Second floor treasure room) (+ Technology 2 on third floor), PC GXSE V7P4 (Treasure Room adjacent to spawn), PC EZTZ CL68 (Treasure Room adjacent to spawn), PC RR0G KKQJ (Treasure Room adjacent to spawn), PC 6FDS 6FWF (Treasure Room adjacent to spawn), PC PCM8 R3H4 (Treasure Room adjacent to spawn), PS4 GXA1 L6XC (Treasure Room adjacent to spawn), PS4 27T2 26G0 (First floor Treasure Room), 3DS 11DA E0JZ (Treasure Room adjacent to spawn), Switch AL2T Q6NC (First Golden Treasure Room), Achievements syringe, needle, injection, purple, grey, gray, Causes Isaac to shrink in size (including hitbox slightly), Can be dropped when exploding mushrooms in the environment that are usually found in the Caves/Catacombs and in secret rooms, * item room, treasure room, item room pool, mushroom, blue, spotted, Adds several instances of The Bible item into all item pools. Dessert = +1 Flat Damage, +0.2 shot speed. Based on the Steam Workshop mod (originally called Lightshot) created by Wyvern and TRPG, Pressing the CTRL key (R2 on PS4, RT on XB1, ZR on Switch) allows you to switch active items, Some items that give temporary effects like The Nail might deactivate if switched to the other slot, Added as part of the Afterbirth+ Booster Pack #4, UNLOCK: Unlock this item by entering every Shop from the first floor up to Mom's Foot (Depths 2) in one run, Grants you a shield when entering the Boss Room, which prevents damage from 1 hit, then disappears. After reflecting a certain number of projectiles, Psy Fly enters a brief cooldown period. The attack can be released only when fully charged. REPENTANCE - The Lost's Holy Mantle can no longer be re-rolled using an item like D4. Ultra Secret RoomTreasure RoomTreasure Room Objects achievement (collect 50 items in a single run), X-Lax - Spawns a pool of slippery brown creep beneath Isaac, Experimental Pill - Increases one random stat and decreases another random stat. Spawns coins as The Keeper, I can see forever - Opens secret room and super secret room entrances on the current floor, I found pills - Changes the appearance of Isaac's face for the current room (Cosmetic change only), Lemon Party - Spawns a large yellow pool on the floor around you, damaging enemies which walk in it, Paralysis - Prevents you from moving for a short while, Pheromones - Applies the charm effect to all enemies in the room for a short while, Puberty - Causes Isaac to grow hair for the rest of the run. After a few seconds, he will quickly attack each target, chaining higher damage for each enemy it hits, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Judas, When used this will cause 8 poison farts that leave a brown creep behind, and then drop 7 Butt Bombs very quickly, Standing in the creep gives you +1 Damage Up and +1.35 Tears Up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Blue Baby, For the current room, 14 Dead Birds fly in from off the screen and attack all enemies, dealing low but frequent damage, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Eve, Isaac gains the Berserk! with Brimstone you get 4 lasers, Counts as 1 of 3 spider items needed towards the Spider Baby transformation, * item room, treasure room, item room pool, green, black, +2 Damage Up for tears fired from Isaac's left eye, If playing as Cain or you have an item which modifies which eye you fire tears from, each shot has a 50% chance to do +2 Damage, * item room, treasure room, item room pool, poison, green, brown, bottle, jar, danger, Gives Isaac an eye companion that floats around the room and deals 8 damage per tick on contact with enemies, Damage from Isaac's left eye deal roughly +35% damage, * item room, treasure room, item room pool, red, white, When you take damage, this item recharges one room's worth of charge to your spacebar item, For example, with the D6 you would need to take damage 6 times to fully recharge it, * angel room pool, god room pool, angel room item, shop room pool, shop item pool, This is decided by whatever you have the least of. UNLOCK: Unlock this item by defeating The Beast as ??? This update brings more than just fixes, the patch also performed some tweaks and changes to the game's health and armor values of some items, so if after a couple of matches you feel like the game is different . An increased damage stat does increase Brimstone's damage. Abel, UNLOCK: Unlock this trinket by defeating Isaac, ?? Trinkets Unlocked from Challenge #24 - PAY TO PLAY, Friends till the end - Spawns three friendly blue attack flies, Infested! Each tick of poison damage is equal to your normal tear damage, Some random tears will gain the Rubber Cement effect and become bouncy, Grants +0.25 Speed, +0.75 Range, +0.1 Shot Speed, +0.2 Tears, +0.5 Damage and +1 Luck when Isaac's active item is fully charged, Infinite use items such as Potato Peeler count as charged and provide the bonus from this trinket, Grants +0.5 Speed, +1.5 Range, +0.3 Shot Speed, +0.4 Tears, +1.5 Damage when Isaac's active item is completely uncharged, One-time use items such as Mama Mega count as uncharged and provide the bonus from this trinket, Gives you another secret room on each new floor while held, Does not spawn more than one super secret room, only the normal secret room, *, purple, torn, ripped, paper, page, poster, When you have the same amount of coins, bombs and keys, half consumables turn into their doubled version, This effect works for any number of consumables, including 0 and 99, as long as the count for coins/keys/bombs is equal, Every time you take damage you have a very small chance to spawn a random pedestal item, When the effect triggers, the trinket is destroyed, Every time you take damage you have a very small chance to spawn the Lunch item, which gives +1 HP up, When the effect triggers, this trinket is destroyed, Increases the radius of any creep you produce, While held, any damage taken remove red hearts first, before soul hearts, black hearts and rotten heart damage, While at 1/2 of a red heart, it will begin to remove your other hearts again, UNLOCK: Unlock this item by beating Greedier mode with Eve, The Walnut has a chance to break when taking damage from an explosion. uses as his main mechanic, Killing or damaging enemies spawns various poops, which add to his collection. 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