Hi, Thank you for this helpful article. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Also, Permethrin is one of the active ingredients in K9 Advantix II, an effective spot-on product Ive used on my Aussie mix with no ill effects. The accidental ingestion of the product may potentially result in . Thank you for such a great article! (I have to give them baths with a very mild or medicated shampoo.) Its worth making a phone call to see what they would recommend for your pup. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. While my pain levels went down, I noticed that my heart rate went up! Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. . Dash is MDR1 mutant/normal. It is also used off-label to control sarcoptic mange and demodectic mange. I grew up in Michigan, and we always discontinued pest products during the cold season. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Your sense of humor is enlightening also. Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. Thanks. a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? And safe travels to you and Lola in the future. Any thoughts on either of these? At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. Two dogs were positive for D. immitis antigen but not MF on days 210 and 236. A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. Any thoughts? Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. According to the Vet UK website, So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. It provides 100% protection from heartworm disease. I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. My dogs are on Sentinel right now and Frontline Gold. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . He loves the taste of Simparica Trio and it's like a treat . Specifically, does it contain any form of -mectin (i.e. Australian Shepherds have a slightly lower incidence, with 50% being affected . Still, if you live in the city and dont walk your dogs through long grass or woodsy areas, this could be a great choice for you. Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. I found a paper on the web written with credits to several vets. Should I give them Trifexis or Sentinel Spectrum? Any suggestions? Simparica Trio is an all-in-one monthly chewable treatment for dogs. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. . Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. (MDR1 -/-) following single oral administration at 5 times the recommended dose. According to Dog Aware, most flea and tick control medications have not been found to cause adverse effects when used as directed, but toxicity can occur iftopicalproducts areingested. This is why reading labels is so important. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. My Collie is double MDR1 mutant. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. $161.99. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. Simparica: The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 . THREE OF THE 8 FEMALES WENT INTO ESTRUS. Thank you for the useful information which is a little easier (clearer) to understand than most. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. Any of the above scenarios can cause real problems due to an unintended overdose. Options: 3 flavors. Perros (mutacin del gen MDR1). So glad you found this useful! - It is easy to administer, with no need for pre-treatment or fasting. The FDA issued an alert to owners and veterinarians and said it was requiring clearer labels on the products. Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . Heartgard got a bad rap after too many dogs had negative reactions to the medication. (One such knockoff, Pet Armor Plus, is even available at Walmart.). Ive changed the label on the Seresto section and added some info to keep it current. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. I had started my GSD on Revolution, but really always liked Frontline better and since that seems to cover more ticks and still protect us from unwanted mites I probably will lean toward that. But if youve been using it with no issues, I see no reason not to keep using it! The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. Simparica TRIO was approved by the U.S. Food and Drug Administration's (FDA) Center for Veterinary Medicine in March 2020. Thanks for your efforts to help! . In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. I gave her Simparica 5 weeks ago for the first time. Hi Vicki, The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. I would say you are right to be concerned, and Ill give some info why. Hi Debbie! I honestly didnt know they existed until I started researching more to answer your question. Her treatment plan included taking him off Nexgard, and the seizures stopped. We will get her in about 3 weeks. She has always had a sensitive stomach, but as she gets older, it gets worse. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). Thank you very much! Due to this fact, Pet Place warns: I have a new Collie-mix with bi-coloured coat. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. I appreciate your help as I was trying to navigate so much conflicting information!! I like Frank so much that I had to give him his own story. First, I want to thank you for the time and effort that went into writing this article. I will try to find the article again, I stupidly didnt bookmark it. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. 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